[HTML][HTML] Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11
KL He, AB Deora, H Xiong, Q Ling, BB Weksler… - Journal of Biological …, 2008 - ASBMB
The annexin A2 (A2) heterotetramer, consisting of two copies of A2 and two copies of
S100A10/p11, promotes fibrinolytic activity on the surface of vascular endothelial cells by
assembling plasminogen and tissue plasminogen activator (tPA) and accelerating the
generation of plasmin. In humans, overexpression of A2 by acute promyelocytic leukemia
cells is associated with excessive fibrinolysis and hemorrhage, whereas anti-A2
autoantibodies appear to accentuate the risk of thrombosis in patients with anti-phospholipid …
S100A10/p11, promotes fibrinolytic activity on the surface of vascular endothelial cells by
assembling plasminogen and tissue plasminogen activator (tPA) and accelerating the
generation of plasmin. In humans, overexpression of A2 by acute promyelocytic leukemia
cells is associated with excessive fibrinolysis and hemorrhage, whereas anti-A2
autoantibodies appear to accentuate the risk of thrombosis in patients with anti-phospholipid …
